Application Note
Directional conjugation of single-domain antibodies enables their application in fluorescence technologies and advanced imaging
This application note highlights the advantages of fluorescent single-domain antibodies in fluorescence-based technologies and advanced imaging.
Due to their small size, labeled sdAbs have a small linkage error leading to robust signals and improved resolution. They are also cleared quickly from the bloodstream and have enhanced tissue penetration leading to good signal-to-noise ratios.
Service Brochure
Functionalizations of single-domain antibodies – Conjugation Services & Reagents
Learn more about:
- QVQ Services
- Directional conjugation of sdAbs
- Service Sheets for sdAb conjugations
- QVQ Products
- Applications of sdAbs in fluorescent technologies and advanced imaging
Blogs
Every sdAb of the (path-)way: targeting factors and complexes across the complement system
The complement system is a crucial part of our innate immune defence, activated by the binding and cleavage of a series of specialized proteins. When the activation or regulation of the complement system is out of balance, it can lead to various diseases. Furthermore, the exact working of the complement system is not fully understood yet. To better understand, measure, and treat the complement system and/or defects thereof, effective detection and modulatory agents are necessary. These tools can be used for both research, diagnostics, and therapeutics.
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Functionalized single-domain antibodies for detection, imaging, and conformational sensing of CXCR4
Single-domain antibodies (sdAbs, also known as VHH) can be derived from heavy-chain-only antibodies from members of the camelidae family like llamas and alpacas. These sdAbs are relatively small in size, stable, and have affinities to antigens that are in a similar range as conventional antibodies. Being single-domain, globular recombinant proteins, sdAbs allow for straightforward genetic modifications, fusion of other proteins, and chemical conjugations.
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Literature
View a list of publications that showcase our single-domain-antibody expertise here.