Butyrophilin B7-DC, also called programmed death ligand 2 (PD-L2) (UniProtKB Q9BQ51), is a member of the B7 family of immune proteins that provide signals for both stimulating and inhibiting T cell activation. Other family members include B7-1, B7-2, B7-H2, PD-L1 and B7-H3. B7 proteins are members of the immunoglobulin (Ig) superfamily, their extracellular domains contain 2 Ig-like domains and all members have short cytoplasmic domains. PD-L2 has been identified as one of two ligands for programmed death-1 (PD-1), a member of the CD28 family of immunoreceptors. The PD-L2:PD-1 pathway is involved in the negative regulation of immune responses and in the regulation of peripheral tolerance.
Source:
Recombinant monoclonal single-domain antibody (Lama glama), purified from S. cerevisiae using affinity chromatography. Immunization with cancer cells. Phage-display selection on recombinant PD-L2 using total elution.
Product details.
Specificity:
Extracellular domain of human PD-L2.
Formulation:
0.2 µm filtered solution in PBS. The products are equipped with a C-terminal C-Direct tag with an unpaired cysteine for directional conjugation.
Mol. Weight:
16 kDa
Ext. Coeff. (ε):
28545 M-1cm-1
A280 at 1g/L:
1.8
Storage:
Shipped on blue ice. Store at 4˚C or -20˚C (aliquots). Addition of 0.02% sodium azide is optional.
