Integrin α3β1 (VLA-3 or CD49c, UniProtKB P26006) belongs to the family of integrins, heterodimeric cell surface receptors that play a pivotal role in cell adhesion, migration, growth and survival. The integrin family contains 18 α- and 8 β-subunits that can form 24 different integrin heterodimers that bind different ligands. Via cooperation with other types of cell surface receptors (e.g. growth factor or G-protein coupled receptors), integrins can regulate intracellular signaling. Integrin beta-1 is the most abundant β-integrin forms dimers with at least 10 different alpha subunits to form for example the Very Late Antigens VLA-3 (α3β1 integrin) or VLA-4 (α4β1 integrin). VLA-3 functions as a receptor for collagen, laminin, and fibronectin and overexpressed in various types of cancer.
Source:
Recombinant monoclonal single-domain antibody (Lama glama), purified from S. cerevisiae using affinity chromatography. Immunization with A431 cells. Phage-display selection on HeLa cells.
Product details.
Specificity:
Extracellular domain of human Integrin α3β1.
Formulation:
0.2 µm filtered solution in PBS. The products are equipped with a C-terminal FLAG tag with an unpaired cysteine for directional conjugation.
Mol. Weight:
14.3 kDa
Ext. Coeff. (ε):
38055 M-1cm-1
A280 at 1g/L:
2.7
Storage:
Shipped on blue ice. Store at 4˚C or -20˚C (aliquots). Addition of 0.02% sodium azide is optional.
