Human serum albumin (HSA) is the most abundant protein in human blood
plasma. Synthesized by the liver, it maintains osmotic pressure, transports
hormones, fatty acids, drugs, and other molecules, and acts as an
antioxidant. It plays a crucial role in fluid balance, nutrient distribution, and
overall physiological homeostasis. HSA is widely used for the half-life
extension of therapeutic molecules because of its naturally prolonged
circulation in the bloodstream, with a serum half-life of approximately 19
days. This extended circulation results primarily from Fc receptor (FcRn)
mediated recycling, which protects albumin from lysosomal degradation.
Source:
Recombinant monoclonal single-domain antibody (Lama glama), purified from S. cerevisiae using affinity chromatography. Immunization and phage
display selection with human serum albumin with total elution.
Product details.
Specificity:
Human serum albumin
Formulation:
0.2 µm filtered solution in PBS. The products are equipped with a C-terminal C Direct tag containing an unpaired cysteine for directional conjugation. The anti-albumin sdAb can be conjugated to other domains for retargeting or half-life extension in the bloodstream.
Mol. Weight:
14.1 kDa
Ext. Coeff. (ε):
18575 M-1cm-1
A280 at 1g/L:
1.32
Storage:
Shipped on blue ice. Store at 4˚C or -20˚C (aliquots). Addition of 0.02% sodium azide is optional.
