Functionalized single-domain antibodies for detection, imaging, and conformational sensing of CXCR4.
Single-domain antibodies (sdAbs, also known as VHH) can be derived from heavy-chain-only antibodies from members of the camelidae family like llamas and alpacas. These sdAbs are relatively small in size, stable, and have affinities to antigens that are in a similar range as conventional antibodies. Being single-domain, globular recombinant proteins, sdAbs allow for straightforward genetic modifications, fusion of other proteins, and chemical conjugations. At QVQ, we offer off-the-shelf sdAbs against a wide range of targets, as well as services for de novo generation, production, and optimization of sdAbs. In addition, we routinely equip sdAbs with an unpaired thiol for directional conjugation to a wide range of commercially available labels.
Every sdAb of the (path-)way: targeting factors and complexes across the complement system.
The complement system is a crucial part of our innate immune defence, activated by the binding and cleavage of a series of specialized proteins. When the activation or regulation of the complement system is out of balance, it can lead to various diseases. Furthermore, the exact working of the complement system is not fully understood […]